Rudolph Research Analytical Autopol V
  • 21CFR Part 11 Compliant
  • Temptrol™ Electronic Heating and Cooling
  • Six standard wavelengths
  • Touch panel user interface
  • Designed for use in FDA regulated Pharmaceutical, Nutraceutical and cGMP/GLP laboratories

The AUTOPOL V Automatic Polarimeter is Rudolph's top of the line six wavelength polarimeter specifically designed with the input of the world's largest pharmaceutical companies. This unit comes standard with 21CFR11 software and Rudolph's Patented TempTrol™ System, which electronically heats and cools the sample to a specified temperature without the use of water circulation. This unit includes all wavelengths necessary to measure 99% of all monographs found in the USP, EP, JP and BP. IQOQ (Installation Quality Operation Quality) documentation is included with the instrument.

AUTOPOL V Polarimeter
Rudolph Research Analytical Autopol IV
  • Measures Optical Rotation, Specific Rotation, Concentration, and User Defined Scales
  • Temptrol™ Electronic Heating and Cooling
  • 1, 2 and 6 wavelength models
  • Temperature Correction
  • Real-time clock
  • Print-out format control
  • Designed for use in Pharmaceutical, University, Essential Oil, and related industries.

The AUTOPOL IV Automatic Polarimeter is available in one, two and six wavelength versions and has a more expensive optical system than the Autopol III. It is the system of choice for research universities, pharmaceutical and fine chemical research departments. This instrument is also excellent for studying recimics and kinetics. Temperature control is accomplished using the patented Rudolph TempTrol™ system. IQOQ documentation is included with the instrument.

AUTOPOL IV Polarimeter
Rudolph Research Analytical Autopol III
  • Measures Optical Rotation, Specific Rotation, Concentration, and °Z (ISS) Sugar Degrees
  • Resolution: 0.001° Arc Optical Rotation
  • Accuracy: 0.002° Arc up to 1°, 0.2% above 1°
  • Simple touch panel user interface
  • Built in temperature probe
  • RS232 & Parallel ports standard
  • Entry level dual wavelength Pharmaceutical and Research grade polarimeter.

The AUTOPOL III Automatic Polarimeter is Rudolph's entry-level pharmaceutical and research grade polarimeter which has a ±0.002 Degrees Optical Rotation accuracy for rotations up to 1° Arc. This polarimeter comes standard with two wavelengths: 589nm and 546nm and will pass an FDA inspection with the appropriate water bath to control temperature. IQOQ documentation is included with the instrument.

AUTOPOL III Polarimeter

Below is an example of why Polarimeters with accuracy of ±0.02 and ±0.01 accuracy polarimeters are not suitable for pharmaceutical applications. Please review the USP monograph for the material Ofloxacin. Ofloxacin must have a specific rotation between +1° and -1° at a concentration of 10mg per ml. Biots Law:

The Autopol I has an accuracy of ±0.02° optical rotation. Below is how its relative accuracy affects a hypothetical Ofloxacin sample:

You cannot successfully inspect a pharmaceutical (such as Ofloxacin) having a Specific Rotation between+1 and ±1 and a 1% concentration, which is quite common for most pharmaceuticals, with an instrument that has an accuracy of ±2.0 in Specific Rotation.

The Autopol IV has an accuracy of 0.002 for Optical Rotations of 1°Arc for a total unknown of +/-0.002 under the same conditions:
Rudolph Research Analytical Autopol II
  • Measures Optical Rotation, Specific Rotation, Concentration, and °Z (ISS) Sugar Degrees
  • Resolution: 0.01° Arc Optical Rotation
  • Accuracy: 0.01° Arc Optical Rotation, 0.03°Z (ISS) Sugar Degrees
  • Simple touch panel user interface
  • Built in temperature probe
  • RS232 & Parallel ports standard
  • Designed as a general purpose dual wavelength Automatic Polarimeter for budget focused Contract Laboratories, Food Laboratories and College Chemistry Laboratories.

The AUTOPOL II Automatic Polarimeter is a general-purpose polarimeter with ±0.01 Degrees Optical Rotation accuracy. This accuracy is applicable for food, university education, many chemical, flavor and fragrance applications, as well as pharmaceutical inspection in some countries. We strongly recommend against using this instrument for USP, EP, JP and BP pharmaceutical applications. Although IQOQ documentation is provided, Rudolph will not perform on-site IQOQ for pharmaceutical applications where a certificate of analysis will be issued. Click here to see the application note on Accuracy of a Polarimeter for Pharmaceutical Applications for clarification.

AUTOPOL II Polarimeter
Rudolph Research Analytical Autopol I
  • Measures Optical Rotation, Specific Rotation, Concentration, and °Z (ISS) Sugar Degrees
  • Resolution: 0.01° Arc Optical Rotation
  • Accuracy: 0.02° Arc Optical Rotation, 0.05°Z (ISS) Sugar Degrees
  • Simple touch panel user interface
  • Built in temperature probe
  • RS232 & Parallel ports standard
  • Designed as a single wavelength polarimeter for Food, Education and less demanding applications where budget is critical, but quality is still important.

The AUTOPOL I Automatic Polarimeter is Rudolph's entry-level model with an accuracy of ±0.02 Degrees Optical Rotation. This accuracy is fine for food and educational applications where budget is critical but state of the art quality is still important. The Autopol I is not a pharmaceutical grade polarimeter and does not come with IQOQ documentation.

AUTOPOL I Polarimeter